She has had her greatest commercial successes with the films Bruce Almighty (2003), The Break-Up (2006), Marley & Me (2008), and Just Go with It (2011).
Aniston was cast in her first television role in 1990, starring as a regular on the short-lived series Molloy and in the TV movie Camp Cucamonga.
Aniston's plans changed, however, after auditioning for Friends, a sitcom that was set to debut on NBC's 1994–1995 fall lineup.The producers of the show originally wanted Aniston to audition for the role of Monica Geller,but Courteney Cox was considered to be better suited to the role. Thus, Aniston was cast as Rachel Green.
In 2007, Aniston guest starred in an episode of Courteney Cox Arquette's series Dirt, playing Arquette's rival, Tina Harrod.
Aniston appeared in the third episode of Season 3 of NBC's 30 Rock playing Liz Lemon's old college roommate who stalks Jack Donaghy. On July 16, 2009, Aniston received an Emmy nomination in the category of Outstanding Guest Actress in a Comedy Series for her role on 30 Rock. Aniston was a guest star on the Season 2 premiere of ABC's sitcom Cougar Town, playing a psychiatrist.
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